GH Stack
CJC-1295 + Ipamorelin — Growth Hormone Research
The GH Stack combines CJC-1295 (a growth hormone-releasing hormone analog) with Ipamorelin (a selective growth hormone secretagogue). In preclinical research, CJC-1295 provides sustained GHRH signaling for prolonged GH elevation, while Ipamorelin offers a selective GH pulse without significant cortisol or prolactin release. Researchers study this combination for synergistic GH axis stimulation. All peptides are sold strictly for laboratory research purposes only.
Research Disclaimer: All content summarizes publicly available preclinical literature. No claims are made about human efficacy, safety, or therapeutic use. Not for human consumption.
Mechanisms of Action
CJC-1295 (with DAC)
- • Synthetic GHRH analog with Drug Affinity Complex
- • Extended half-life (~6-8 days vs minutes)
- • Sustained GH release over multiple days
- • Increases IGF-1 levels in animal models
- • Studied for growth, recovery, and body composition
Ipamorelin
- • Selective GH secretagogue (ghrelin mimetic)
- • Stimulates pulsatile GH release
- • Minimal cortisol/prolactin elevation
- • Shorter acting — mimics natural GH pulses
- • Studied for targeted GH modulation
Synergy Rationale
CJC-1295 provides a sustained baseline elevation of GHRH signaling, while Ipamorelin adds targeted pulsatile GH release. Together, researchers study amplified yet more physiologic GH patterns compared to either peptide alone.
Common Research Protocols
| Component | Research Dose | Frequency | Administration | Duration |
|---|---|---|---|---|
| CJC-1295 (DAC) | 1–2 mg/week | 1–2x per week | Subcutaneous | 8–12 weeks |
| Ipamorelin | 200–300 mcg/dose | 2–3x daily | Subcutaneous | 8–12 weeks |
| Combined Stack | As above | Per individual schedules | Separate injections | 8–12 weeks + washout |
Frequently Asked Questions
Why combine CJC-1295 with Ipamorelin?▼
CJC-1295 provides sustained GHRH signaling for baseline GH elevation, while Ipamorelin adds selective pulsatile GH release. The combination aims to amplify GH output while maintaining physiologic patterns.
What is the DAC in CJC-1295?▼
Drug Affinity Complex (DAC) extends the half-life from minutes to approximately 6-8 days by binding to serum albumin. CJC-1295 without DAC (also called Mod GRF 1-29) has a much shorter duration.
Does Ipamorelin affect cortisol or prolactin?▼
Unlike other GH secretagogues (GHRP-6, GHRP-2), Ipamorelin shows minimal cortisol and prolactin elevation in preclinical studies, making it a more selective research compound.
What purity is required?▼
HPLC-verified ≥99% purity is recommended for reproducible results. NovaPure Labs includes third-party COAs with every peptide order.